Notably, greater attention should be directed towards grade ≥ 3 adverse events with a potential inflammatory or immunologic cause, including pruritus (RR = 17.07 [95% CI 0.99–295.31]), hypopituitarism (RR = 9.05 [95% CI 0.491–67.81]), increases in ALT (RR = 6.50 [95% CI 2.30–18.41]) or AST (RR = 6.33 [95% CI 1.89–21.19]), and type 1 diabetes mellitus (RR = 5.51 [95% CI 0.70–45.75]) (Supplementary Table 3). The gene discussed is GPT; the disease is Pruritus.