Furthermore, GADD45A+ myofibers were specifically related to type 2A myofibers and spatially associated with T cell infiltrates as opposed to RNF7+ myofibers, suggesting different pathways of myofiber atrophy in IBM: (1) T cell-driven inflammation and genomic stress (GADD45A, lncRNA NORAD) and (2) degenerative processes involving protein degradation and autophagy (RNF7, p62). The gene discussed is GADD45A; the disease is inclusion body myositis.