CD274 and cancer: The functional analysis of the DEGs modulated by 1.8 μM AFB1 in CYP1A1 KO cells vs CTL revealed the enrichment of four pathways (Supplementary Fig. 3a) which were mainly related to cell proliferation (i.e., ‘PD-L1 expression and PD-1 checkpoint pathway in cancer’, ‘AGE-RAGE signaling pathway in diabetic complications’, ‘Choline metabolism in cancer’ and ‘Relaxin signaling pathway’).