Initially, uni-Cox regression analysis revealed correlations between poor prognosis in CRC and factors such as TCGA subtype (HR = 1.697, 95%CI = 1.249–2.355, p = 0.002), TNM (T: HR = 3.751, 95%CI = 1.522–9.245, p = 0.004; N: HR = 3.314, 95%CI = 2.186–5.024, p < 0.001; M: HR = 3.827, 95%CI = 2.471–5.929, p < 0.001), pathological stage (HR = 2.814, 95%CI = 1.849–4.284, p < 0.001), age (HR = 1.023, 95%CI = 1.006–1.040, p = 0.009), and USP21 expression (HR = 2.244, 95%CI = 1.841–2.680, p < 0.001). Here, USP21 is linked to colorectal carcinoma.