PTBP1 and hepatocellular carcinoma: In addition, polypyrimidine pathway binding protein 1 (PTBP1) has been shown to mediate ferroptosis in hepatocellular carcinoma cells by regulating the translation of NCOA4, and the PTBP1-NCOA4 axis may be an important pathway for ferritinophagy-mediated ferroptosis [48].