Modulation of NRF2-associated signaling pathways attenuates ferritinophagy and ferroptosis after cerebral ischemia/reperfusion, with the Keap1-NRF2-HO-1 signaling pathway being a crucial pathway to combat oxidative stress and regulate ferroptosis after CIRI [62].Therefore, NRF2 might be a potential target for regulating ferritinophagy and ferroptosis. The gene discussed is HMOX1; the disease is brain ischemia.