Firstly, as in the clinic, cell death responses to FET treatment in PDEs is dependent on histological subtype: mucinous carcinomas, which typically have a more favourable prognosis clinically57, undergo significantly more tumour apoptosis/necrosis in response to FET compared to invasive ductal carcinomas while, in terms of molecular subtypes, HER2-positive tumours underwent significantly less apoptosis/necrosis compared to Luminal A and TNBCs. This evidence concerns the gene ERBB2 and neoplasm.