Derived from these serum indicators, such as albumin-bilirubin index (ALBI) [9], platelet-albumin-bilirubin index (PALBI) [11], platelet-albumin index (PAL) [12], gamma-glutamyl transpeptidase-to-platelet ratio (GPR) [13], AST/ALT ratio (AAR) [14], fibrosis-4 (FIB-4) and aspartate-aminotransferase-to-neutrophil ratio index (ANRI) [15] are considered as the novel and non-invasive indicators for evaluating liver function or liver fibrosis of the patients with chronic liver diseases. The gene discussed is ALB; the disease is Hepatic fibrosis.