IQGAP1 and acute myeloid leukemia: Proteomic analyses of the affinity-purified lysates of primary AML samples were conducted using the strategy of depletion followed by enrichment as shown in Fig. 1B. In LC–MS/MS experiments done with three separate AML samples and repeated with one of those three samples, IQGAP1 was noted to be differentially recognized (Proteomics data are deposited in the PRIDE database (https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD040171).