IQGAP1 and acute myeloid leukemia: IQGAP1 is overexpressed in primary AML cells: Rabbits (NZ white, Covance) were immunized subcutaneously weekly × 16 weeks with FDNB-modified or -unmodified human WBC cells as shown in Fig. 1A. After heat inactivation of complement, the immune sera were absorbed against pooled WBCs from normal healthy subjects.