Similar to AML, as reported here, disrupting IQGAP1-mediated PI3K expression and functions via IQ3 peptide inhibited human HNSCC cell survival, proliferation, migration, and invasion, indicating importance of IQGAP1 as a therapeutic target in a broad range of malignancies43,44. Here, IQGAP1 is linked to head and neck squamous cell carcinoma.