IQGAP1 and acute promyelocytic leukemia: Similarly, BloodSpot analysis28 showed that compared to normal hematopoietic cells, AML-subtypes including acute promyelocytic leukemia (APL) [(AML t(15:17)], acute myeloid leukemia carrying inv(16)/t(16;16), t(8;21), or 11q23 chromosomal abnormalities, and AML with complex karyotype showed increased IQGAP1 mRNA expression (p =  < 0.001 vs HSC, Students T test) (Fig. 1G).