We found that low levels of fat mass and obesity-associated gene (FTO) in older livers promoted the posttranscriptional m6A modification of acyl-CoA synthetase long chain family 4 (Acsl4) and Tfrc, which are two general contributors to ferroptosis sensitivity, and induced their expression during IRI. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.