Moreover, an analysis by Daly et al. of 130,151 BC patients using a 25-gene panel revealed that young age (≤ 45 years) at diagnosis was strongly associated with presence of PVs for BRCA1 (OR 3.95, 95% CI 3.64–4.29), moderate for BRCA2 (OR 1.98, 95% CI 1.84–2.14), modest associations for ATM (OR 1.22, 95% CI 1.08–1.37) and CHEK2 (OR 1.34, 95% CI 1.21–1.47) genes, and not associated with PVs for PALB2 (OR 1.12, 95% CI 0.98–1.27)46. This evidence concerns the gene CHEK2 and breast cancer.