However, acknowledging the ongoing importance of LC in atopic dermatitis, additional research is needed to elucidate how significant genetic factors (Trp73, Orm-1, Chi3l3, Ccl20, AnXa1, Alox5, Ccr1, and Fcεr1a, etc.)identified in our study may interact with LC function and the disease process. This evidence concerns the gene ALOX5 and atopic eczema.