NPPB and congestive heart failure: We detected the N-terminal pro-brain natriuretic peptide (NT-proBNP), a cardiac hormone for the diagnosis of patients with acute or chronic heart failure, in the blood of the AAV9-control and AAV9-miR-654-3p sponge-infected mice, which showed a slight promotion in the AAV9-miR-654-3p group (Fig. 2G).