SIN has been demonstrated to decrease the levels of inflammatory factors (TNF-α, IL-6, etc.)in IL-1β-induced RA-fibroblast-like synoviocytes (FLS), as well as the expression of toll-like receptor 4 (TLR4), myeloid Differentiation Primary Response Protein 88 (MyD88), p-NF-kB p65, and tumor necrosis factor receptor-associated factors 6 (TRAF-6)22,23. The gene discussed is TLR4; the disease is rheumatoid arthritis.