Although Fbp1 homozygous (Fbp1−/−) newborn mice were morphologically indistinguishable from WT littermates (Fbp1+/+) (Supplementary Fig. 2e), they died several days after birth, which might be caused by hypoglycemia and lactic acidosis observed in FBP1 deficient human infants [12]. Here, FBP1 is linked to Hypoglycemia.