Additionally, the glycolytic enzyme PFKFB3 is overexpressed in the skin of psoriasis patients, and in the skin of IMQ-mouse model [5, 51], which may well be involved in the activation of glycolysis, together with the downregulation of FBP1. Moreover, consistent with the decreased expression of FBP1 in clear cell renal cell carcinoma, breast cancer and hepatocellular carcinoma [13–16], we find FBP1 is also downregulated in SCC, implicating the tumor suppressive role of FBP1 in skin carcinoma. This evidence concerns the gene PFKFB3 and breast cancer.