We next addressed whether the effect of HDACis on EVI1 was at least partly related to PA2G4 and showed that PA2G4 knockout abrogates EVI1 and consequently MYC protein (Fig. 6D); it then prevents the growth and formation of colonies in 3q26 AML (Supplementary Fig. 10A, B). This evidence concerns the gene MYC and acute myeloid leukemia.