The acute myeloid leukemia (AML) model that carries a 3q26 defect such as the inv(3)(q21q26), t(3;3)(q21;q26), ins(3;3)(q26;q21q26), t(3;8)(q26;q24), and t(3;21)(q26;q22) involving the TF Ecotropic Virus Integration EVI1 [MDS and EVI1 complex locus (MECOM)]3 in the 3q26 locus exemplifies aggressiveness, with the poorest overall survival (OS) and refractoriness against conventional chemotherapy4,5. The gene discussed is MECOM; the disease is acute myeloid leukemia.