Interestingly, PA2G4 is part of a transcriptional core signature of four genes (DNMT1, MYB, PA2G4, and YBX1) repressed with de-differentiation in all-trans retinoic acid-induced NB4 and HL60 AML cell lines, suggesting that PA2G4 plays a role in AML maintenance84. This evidence concerns the gene YBX1 and acute myeloid leukemia.