The functional interaction of EVI1 with the HDAC complexes was initially postulated in heterologous cells transfected with different EVI1 cDNAs isoforms64–66 or by quantitative proteomics combined with yeast two-hybrid screens and subsequently validated by coimmunoprecipitation experiments with endogenous EVI1 in cancer cell lines40. The gene discussed is RUNX1; the disease is cancer.