Conversely, the overexpression of PA2G4 increased EVI1 and MYC protein levels (Fig. 6E and Supplementary Fig. 10C) and partially rescued AML cells from the apoptotic effect of HDAC inhibition (Fig. 6F), suggesting that PA2G4 is a putative mediator of HDAC inhibition. Here, RUNX1 is linked to acute myeloid leukemia.