RUNX1 and leukemia: Similarly, PA2G4 is positively correlated with MYC expression in AML primary datasets (GSE14468, n = 524 and GSE134589, n = 672; Supplementary Fig. 9I)45,46 and interestingly, both EVI1 and MYC occupy the promoter region upstream PA2G4 transcription site (Supplementary Fig. 9J), suggesting that these genes are required for PA2G4 control in 3q26 leukemia (Fig. 6B).