Existing studies have demonstrated that Luteolin can attenuate LPS-induced myocardial injury by activating AMPK-mediated autophagy54, suppress THP-1 macrophage pyroptosis by inhibiting ROS production through Nrf2 activation and NF-κB inactivation55, and mitigate breast cancer hallmarks by downregulating Nrf2-mediated gene expressions56. Here, NFKB1 is linked to breast cancer.