In NASH patients, we have seen several significant changes in sphingolipids, such as Cer (d18:1/16:0), Cer (d18:1/14:0), Cer (d18:1/20:0), Cer (d18:1/22:0), Cer (d18:1/18:0) and Cer (d18:1/18:0). The gene discussed is CBLN1; the disease is metabolic dysfunction-associated steatohepatitis.