EPAS1 and metabolic dysfunction-associated steatohepatitis: To further verify the role of macrophage HIF-2α overexpression in NASH and investigate whether macrophage-specific HIF-2α overexpression could confront the effects of So(d18:1) on NASH in vivo, Hif2α+/+ and LysMHif2αLSL/LSL mice were fed a CDAA-HFD with vehicle or So(d18:1) injection for 8 weeks.