To explore the roles of CUL3, KLHL9 and KLHL13 in degradation of mitochondrial substrates dependent on BipD, we found the protein level of IMMT was increased under the knockdown of Cul3, Klhl9 or Klhl13, respectively, upon B. pseudomallei WT infection, whereas the effect was abrogated under ΔbipD infection in RAW264.7 cells (Fig. 5f). Here, CUL3 is linked to infection.