To corroborate whether IMMT ubiquitination, mediated by the KLHL9/KLHL13/CUL3 complex, impacts the virulence and intracellular viability of B. pseudomallei in vivo, BALB/c mice were subjected to infection with B. pseudomallei WT or ΔbipD via intraperitoneal injection, along with MLN4924 treatment. The gene discussed is KLHL9; the disease is infection.