BRCA1 and cancer: Larger number of carriers at older ages, with a larger number of incident cancers, will be required to assess the predicted risks with greater precision, in particular among different risk categories.26 BOADICEA assumes that the joint effects of BRCA1/2 PVs with the PRS and QRFs are multiplicative on the risk scale,6 7 but studies suggested that deviations from the multiplicative model may exist.2 5 The BOADICEA model assumes an age-dependent effect of the PRS, as previously described2 and the present study suggests the BOADICEA assumptions provide valid risks for BRCA1/2 PV carriers.