Evidence supporting this phenomenon includes the rapid expansion of selected T cell receptor clones recognizing a neoantigen expressed by the Karyopherin Subunit Alpha 2 (KPNA2) gene, upregulated by RT, in the blood of a nonsmall-cell lung cancer (NSCLC) patient responding to RT and CTLA-4 blockade.32 Here, KPNA2 is linked to lung cancer.