In tumour tissues, CD73 mediated-degradation of ATP into AMP replenishes the TME with immunosuppressive adenosine, which inhibits immune responses by binding to A2A and A2B adenosine receptors located on immune cells, resulting in a tolerogenic phenotype of DCs, decreased cytotoxic activity of CD8+ T cells, and an increase in immunosuppressive macrophages and regulatory Tregs.51 The gene discussed is CD8A; the disease is neoplasm.