We hypothesize that SSLs, which are precursors to CRCs with high microsatellite-instability that have better prognosis, have greater immune cell infiltration in the epithelial tissue (greater proportion of CD3+ cells), greater expression of MUC5AC in the tumor region, and that cells expressing MUC5AC spatially attract macrophages (CD68+ cells) in SSLs, but not in adenoma samples (Chen et al. 2021). The gene discussed is MUC5AC; the disease is neoplasm.