For example, recent findings demonstrate differences in immune cell infiltration of colorectal precancerous polyps such as a higher concentration of CD8+ T-cells in the epithelium of sessile serrated lesions (SSL) than that of conventional adenomas and higher CD68+ macrophages concentration at the luminal surface in SSL, but more randomly distributed in adenomas (Chen et al. 2021). This evidence concerns the gene CD8A and adenoma.