In a small study including 24 patients with pathological CRP values (>5 mg/L), a trend for a positive correlation between CRP and olanzapine C:D ratios was observed.59 In a larger study including 354 patients, a population pharmacokinetic model showed that the cooccurrence of infection decreased olanzapine clearance by 25% on average.37 Additional studies should be performed to further assess the association between CRP and olanzapine plasma concentrations. Here, CRP is linked to infection.