9,10,24 Chronic low-dose exposure to various brominated flame retardants led to fasting hyperglycemia and altered plasma insulin levels in rodents.21–23 Additionally, treatment of an immortalized β-cell line (INS-1E) with two brominated flame retardants, PBDE-47 and PBDE-85, increased insulin secretion in vitro. This evidence concerns the gene INS and Hyperglycemia.