DP-exposed islets from three of five donors exhibited altered insulin release under HG conditions, with ND donor R362 showing increased secretion in 1 nM DP conditions (Figure 4(a)) and T2D donors R401 and R402 showing decreased secretion in 10 nM or 1 nM DP conditions, respectively (Figure 4(j,m)). Here, INS is linked to type 2 diabetes mellitus.