SMOX and disease arising from reactivation of latent virus: We next tested several mutant lines affecting melanization, which all displayed a greatly increased sensitivity to ingested PAO1 in the latent infection model, with the exception of the ΔPPO1, ΔPPO2 or Hayan single mutant strains for which 50% or less of the flies succumbed to the infection within two weeks (Figs 3C and S3D).