Autoantibodies to desmogleins 1 and 3 were measured in paired serum samples from 23 pemphigus patients who received SARS-CoV-2 vaccination, including 14 patients with Pre V and Post V1 paired samples (10 PV, 4 PF) and 9 patients with Pre B and Post B1 paired samples (8 PV, 1 PF). This evidence concerns the gene DSG1 and pemphigus.