There were no differences in CD4 and CD8 responses at the Post V1 visit between patients with the most represented autoimmune diseases in our cohort, except for patients with SLE who had lower CD4 and CD8 responses than patients without SLE after correcting for medication use (P < 0.05 and P < 0.001, respectively; Figure 5, C and D). Here, CD4 is linked to autoimmune disease.