Our hypotheses were based on the reasoning that the immediate immune response to HIV infection will activate HIV-specific CD4+ T cells to initiate an antiviral response and HIV will infect and integrate into these genes, and during untreated chronic HIV infection, herpesviruses will recur and HIV-specific CD4+ T cells will express high levels of exhaustion markers, such as Tim3 and PD-1, compared with healthy controls (21, 22), and HIV will infect and integrate into expressed genes. This evidence concerns the gene CD4 and HIV infectious disease.