During untreated chronic HIV infection, CD4+ T cells specific for human herpesviruses, including Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpes simplex viruses types 1 and 2 (HSV1 and -2), as well as for HIV and other infections, become activated and serve as targets for HIV infection (13). Here, CD4 is linked to infection.