Since Blimp-1 can instruct tissue residency and exhaustion markers (68, 99–101), and we found an increased exhaustion phenotype in CD8+ T cells in the skin, we speculate that hypoxia-driven Blimp-1 expression may also initiate the CD8+ T cell program of exhaustion within cutaneous leishmaniasis lesions, which requires further investigation. The gene discussed is PRDM1; the disease is cutaneous leishmaniasis.