It is also unknown whether the presence of anti-thyroid antibodies (ATAs) [anti-thyroglobulin antibody (TgAb) and/or anti-thyroid peroxidase antibody (TPOAb)] at baseline, which is a risk factor for thyroid dysfunction induced by PD-1-Ab [9, 10, 24, 25], could affect thyroid dysfunction induced by PD-(L)1-Ab/TKI as well. This evidence concerns the gene CD274 and thyroid gland disorder.