A similar conclusion was obtained in a model of the proliferation in ESCC cells, where FTO reduced the m6A modification of LncRNA LINC00022, and inhibited LINC00022 decay via YTHDF2, contributing to LINC00022 directly binding to p21 protein and promoting its ubiquitination-mediated degradation (Cui et al. 2021). This evidence concerns the gene FTO and esophageal squamous cell carcinoma.