For example, in a study of 43 cases of neuroblastoma, TPX2 was found to positively regulate the proliferation, cell cycle, and survival of neuroblastoma cells, which have an oncogenic role in the development of neuroblastoma, indicating the value of TPX2 as a prognostic indicator in neuroblastoma (Koike et al. 2022). This evidence concerns the gene TPX2 and neuroblastoma.