TPX2 and cancer: Increasing evidence has demonstrated the close involvement of TPX2 in multiple malignant tumors (such as esophageal, prostate, lung, breast, and gastric cancers) (Zou et al. 2018a; Sui et al. 2019; Yang et al. 2015; Tomii et al. 2017; Zhou et al. 2020; Neumayer et al. 2014).