Further multivariate Cox analysis identified six genes that were independently associated with the survival of patients with HCC, including TPX2 (HR = 1.84), KIF2C (HR = 1.64), CENPA (HR = 1.62), KIF20A (HR = 1.61), CCNB2 (HR = 0.44), and TOP2A (HR = 0.60) (all p < 0.05, Fig. 9C). The gene discussed is TOP2A; the disease is hepatocellular carcinoma.