We observed that the rare missense mutations in INPPL1 were associated with decreased average cortical thickness in AD signature brain regions (p = 0.02) in the EMIF-AD MBD cohort and were associated with increased CSF neurofilament light chain (NfL) levels (p = 0.04) in the ADNI cohort [51]. This evidence concerns the gene INPPL1 and Alzheimer disease.