Recent network-based approach studies have revealed that upregulation of SHIP2 (SH2 domain-containing Inositol 5-Phosphatase 2) transcripts encoded by INPPL1 (Inositol Polyphosphate Phosphatase Like 1) is significantly associated with cognitive decline and neuropathological lesions in human AD and aging brains [65] and that INPPL1 is one of the most significant AD-associated genes that can be potential diagnostic biomarkers and therapeutic targets for AD [24]. The gene discussed is INPPL1; the disease is Alzheimer disease.