INPPL1 and Alzheimer disease: We, therefore, queried genetic association analyses on INPPL1. While there were no suggestive (p < 1 × 10–5) variants within 1 Mb of INPPL1 gene coordinates in the stage I GWAS of AD risk [13] and of CSF Aß42 and pTau biomarkers [46] (Fig. 8), we observed three subthreshold association signal peaks for AD risk and CSF pTau levels in proximity of INPPL1, tagged by three single nucleotide polymorphisms (SNPs).