In line with the observation of the human post-mortem brain tissue of FTD-tau with MAPT mutation (Fig. 4j–l), there was no significant difference observed in SHIP2 (3E6) immunolabelling in the brain of Tg30 mice overexpressing human double mutant tau compared to wild-type mice (Fig. 5a–b). This evidence concerns the gene MAPT and frontotemporal dementia.