Specifically, concentrations of the inflammatory cytokines IL-8, IL-6, IL-10, INF-γ and IL-12P70, were significantly increase in the prostate cancer group compared to the control group; while, the concentrations of IL-4, IFN-α, TNF-α and IL-1β were significantly lower than those in the control group. This evidence concerns the gene TNF and Familial prostate cancer.