CD274 and neoplasm: In studies related to GZMB, it was observed that in the PD-L1-positive group, Kaplan–Meier analysis revealed better recurrence-free survival (RFS) and OS in triple-negative breast cancer (TNBC) patients with high expression of GZMB (defined as ≥ 1% tumor-infiltrating lymphocytes (TILs) positive).