The expression of ki67, K6, and MCP-1 was significantly increased and F4/80 was significantly reduced in the dorsal skin tissues of the TAN-H + Clo-A group compared with the TAN-H group (P < 0.05, Fig. 4F-K), showing that TAN may act on psoriasis through macrophages. Here, MKI67 is linked to psoriasis.