Compared with the model group, the TAN-H group significantly reduced the levels of iNOS, TNFα, IL-6, IL-20, MIF, MCP-1, MIF, and significantly elevated the levels of CD206 and IL-4 (P < 0.01, Fig. 3), demonstrating the ameliorative effect of TAN-H on macrophage polarization and inflammation at the skin lesion site in psoriasis mice. This evidence concerns the gene CCL2 and psoriasis.