HES1 and psoriasis: In this part, we analyzed the effect of TAN on Notch signaling pathway in skin lesion tissues of psoriasis mice, as shown in Fig. 5, the expression of Notch1, Hey1, and Hes1 in the dorsal skin tissues of the model group was significantly activated compared with that of the control group, and the TAN-M and TAN-H treatments significantly inhibited the expression of Notch1, Hey1, and Hes1 in the model mice (P < 0.01), revealing that TAN inhibited the Notch signaling pathway.