KMT2C and esophageal squamous cell carcinoma: The co-occurrence and exclusion relationship of the mutated genes in ESCC is demonstrated in Fig. 4B. Among the top 50 frequently mutated genes, KMT2C and TET1 had the most frequent co-occurrence relationship with other 13 genes in mutation, hinting the important role of epigenetic regulators in ESCC pathogenesis and development.