Several tyrosine kinases (that is, FGF3, FGF4, FGF12, and FGF19) and receptors (that is, EGFR and ERBB2) exhibited CN gains, as well as their downstream signal transducer PIK3CA and AKT3, together contributed to the proliferation of ESCC. The gene discussed is AKT3; the disease is esophageal squamous cell carcinoma.