Several tyrosine kinases (that is, FGF3, FGF4, FGF12, and FGF19) and receptors (that is, EGFR and ERBB2) exhibited CN gains, as well as their downstream signal transducer PIK3CA and AKT3, together contributed to the proliferation of ESCC. This evidence concerns the gene FGF4 and esophageal squamous cell carcinoma.