CD274 and cancer: Cancer immunotherapy methods include, among others: monoclonal antibodies (checkpoint mAbs, therapeutic mAbs), small molecule drugs (targeting PD-1/PD-L1 axis, STING agonists, CXCRs inhibitors), adoptive cell therapy (CAR-T, TCR-T, TILs, CAR-NK) oncolytic viruses (adenoviruses, HSV-1) and cancer vaccines (dendritic cells stimulated ex vivo) [1].