When coupled with phosphodiesterase 3A (PDE3A), SLFN12 can increase tumor sensitivity to 6-(4-(diethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one (DNMDP) in lung adenocarcinoma cell lines [13]. The gene discussed is SLFN12; the disease is neoplasm.