SLFN12 and neoplasm: This review sought to better understand the 12th member of the SLFN family by evaluating the existing data on SLFN12. Based on the prior literature, this article's review suggested that SLFN12 might have a function in immune cell differentiation, apoptosis, control viral replication and pathogenicity, increase tumor sensitivity to chemotherapeutics, and SLFN12 levels may be utilized to modify or anticipate the effects of radiation and chemotherapy.