Previous research has shown that high expression levels of HDAC1 were correlated with obesity and overweight in HFD-fed mice (Choi et al., 2017), while there was also a study showing the expression of HDAC1 in adipose tissues from obese women was lower in comparison with normal-weight individuals (Pour et al., 2020). Here, HDAC1 is linked to obesity due to melanocortin 4 receptor deficiency.