KEGG pathway analysis revealed that four hub genes- ABL1, HDAC1, HDAC2 and MDM2 - were primarily associated with chronic myeloid leukemia (KEGG:05220 and P = 3.27E-08) and notch signaling pathway (KEGG:04330 and P = 2.38E-04). This evidence concerns the gene MDM2 and chronic myelogenous leukemia, BCR-ABL1 positive.