(3) Induced tumor matrix angiogenesis: High-level BIRC5 expression in tumor tissues increases the level of β-catenin protein, enhances the transcriptional activity of β-catenin/Tcf-Lef, and promotes the expression of VEGF, thus contributing to angiogenesis in tumor stroma (Fernández et al., 2014). This evidence concerns the gene HNF4A and neoplasm.