VEGFA and osteochondritis dissecans: As adipokines and VEGF exerts direct and indirect effects on bone metabolism and blood vessels, they might also be implicated in the development of several bone diseases including osteoporosis, osteochondrosis and osteochondritis dissecans (OC/OCD) like lesions, avascular necrosis of the femoral head and canine hypertrophic osteodystrophy (Figure 1) (42–45).