Using the top eight upregulated genes (SLPI, PLA2G2A, CXCL1, CCL20, REG1A, CLDN7, PI3, LGALS3) as a representative gene set for the high metabolic subcluster, we calculated the GSVA score of this gene set for each patient in the TCGA gastric cancer cohort. The gene discussed is SLPI; the disease is gastric cancer.