Furthermore, gene set analysis revealed prominent changes in Wnt, MAPK, Notch, TGF-beta, JAK-STAT, and cytokine and chemokine signaling, as well as changes in cytotoxicity, metabolic stress and myeloid and lymphoid compartment (Figure 2C), showcasing that increased AREG leads to significant tumor intrinsic immune changes that can contribute to cell proliferation, migration, and angiogenesis, while simultaneously promoting tumor immune suppression. Here, SOAT1 is linked to neoplasm.