BECN1 and neoplasm: The micelles loaded with DOX and shBeclin1 enhanced the anti-tumor effect of DOX by blocking the Beclin1 protein-mediated autophagy process, leading to synergistic cell apoptotic induction in HeLa cells and revealing superior anti-tumor efficacy of FR-targeted micelles when compared with non-FR-targeted micelles or free DOX (Chen et al., 2018).