Reduced eNOS activity and reduced nitric oxide levels were found in induced pluripotent stem cell (iPSC)-derived endothelial cells from HGPS patients, along with increased expression of pro-inflammatory molecules and reduced flow-induced gene expression (Atchison et al., 2020; Gete et al., 2021), suggesting that progerin perturbs endothelial flow-mediated responses and promotes inflammation. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.