As well, CM manifests significant intratumor and intertumoral heterogeneity, and varies by pathologic features (e.g., Breslow depth), transcriptomics, proteomics, and genomics.224 In the latter case, there are at least four genetic subtypes of melanoma (e.g., mutant BRAF, mutant RAS virus, mutant neurofibromatosis type 1 [NF1], and Triple-Wild-type) which may differentially interact with MAP.225. The gene discussed is BRAF; the disease is melanoma.