Independent of UV radiation, CMs often present in mixed cancer syndromes attributable to “mutations in PTEN, BRCA2, BRCA1, RB1, and TP53.”195 The “epithelioid cytology of melanocytic tumors may suggest an underlying BAP1 mutation,” frequently characterized as BAP1 tumor predisposition syndrome (BAP1-TPDS). The gene discussed is BAP1; the disease is BAP1-related tumor predisposition syndrome.