HAVCR1 and cancer: In addition, upregulation of TIM-1 expression controls the pathogenesis and progression of cancer by regulating activation of p53 and mTOR, downregulating expression of B-cell lymphoma-2 (Bcl-2)-associated X-protein (BAX), upregulating expression of Bcl-2, and inhibiting apoptosis in cancer cells (Banno et al., 2020).