Particularly in breast carcinoma, Ang-2 contributes to colonization of circulating cancer cells in the brain during the early stages of the metastatic cascade in a mouse model of breast cancer metastasis.5 These findings reflect our observations in patients diagnosed with BM, showing increased Ang-2 expression in brain microvascular endothelial cells already at the early stages of brain colonization. The gene discussed is ANGPT2; the disease is breast cancer.