ANGPT2 and cancer: Early expression of Ang-2 in stroke has been described by Beck et al.37 Furthermore, Ang-2 GOF experiments in murine vasculature led to impairment of the BBB, which was rescued by targeting Tie2 in a middle cerebral artery occlusion model (MCAO).29 So far, it is unclear, whether a complete infarction-like lesion is necessary for the process of cancer cell extravasation into the brain.