In patients with West Syndrome, a type of epileptic encephalopathy characterized by infantile spasms, intramuscular ACTH and oral corticosteroids result in seizure reduction up to complete seizure freedom and improvement of electroencephalogram (EEG) findings defined by the disappearance of hypsarrhythmia.7, 8, 9. Here, POMC is linked to infantile spasms.