Our screening procedure was robust as a subset of the highly ranked genes (BAX, BIM, BAP1, and SPRED2) had previously been correlated to either CML progression, imatinib resistance, or resistance to alternative therapies in different cancer types.24, 34, 35, 36, 37. Here, BAP1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.