IFI16 and nonpapillary renal cell carcinoma: Compared to the normal renal tubular epithelial cell line HK-2, RT-qPCR and western blotting experiments revealed that, at both the transcriptional and translational levels, ccRCC cell lines, except for the OS-RC-2 cell line, the 769-P, 786-O, ACHN, and Caki-1 cell lines exhibited significantly elevated expression of IFI16 (Fig. 2D, E).